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Home - Products - Angiogenesis - HIF/HIF Prolyl-hydroxylase - BMS202 hydrochloride

BMS202 hydrochloride

CAS No. ——

BMS202 hydrochloride ( —— )

Catalog No. M17711 CAS No. ——

PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BMS202 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM).
  • Description
    PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    PD-1/PD-L1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    455.97
  • Molecular Formula
    C25H30ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.COc1nc(ccc1CNCCNC(C)=O)OCc3cccc(c2ccccc2)c3C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zak KM, Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).Oncotarget. 2016 May 24;7(21):30323-35.
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